Table 3 Association of rs3858704 and rs6028718

From: Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Phenotype

Case

Control

rs3858704 (12q24.12)

rs6028178 (20q12)

RAF

P

OR

RAF

P

OR

Case

Control

Case

Control

IONFH

1,547

59,103

0.726

0.672

2.97 × 10−12

1.33

0.588

0.521

7.05 × 10−14

1.32

Stratified analysis based on risk factors

Alcohol-associated

351

59,103

0.844

0.672

1.23 × 10−21

2.73

0.629

0.521

1.98 × 10−8

1.56

Steroid-associated

1,058

59,103

0.691

0.672

0.0186

1.12

0.574

0.521

6.84 × 10−7

1.25

Neither-associated

132

59,103

0.696

0.672

0.246

1.17

0.587

0.521

0.0298

1.31

Stratified analysis based on alcohol intake*

Alcohol-associated

351

3,647

0.844

0.817

0.0404

1.26

0.629

0.519

1.43 × 10−8

1.61

  1. *Controls were matched for alcohol-drinking history (400 ml or more ethanol consumption per week). RAF: risk allele frequency, OR: odds ratio, IONFH: idiopathic osteonecrosis of the femoral head.
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