Figure 2 | Scientific Reports

Figure 2

From: Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter

Figure 2

RA signaling controls ureteric mesenchymal differentiation. Hematoxylin and eosin (upper panel) and co-immunofluorescence analysis of GFP and TAGLN (lower panel) on transverse proximal sections of E11.5 + 14d (A), E12.5 + 12d (B), E14.5 + 10d (C), E16.5 + 8d (D) and E18.5 + 6d (E) Tbx18 cre/+; R26 mTmG/+ ureter explants that were treated with DMSO, 1 µM BMS493 or 1 µM RA. The bar graph displays ratios of differentiated cell types that were quantified based on the immunofluorescence analysis. RA signaling acts from E11.5 to E14.5 to maintain lamina propria cells at the expense of SMCs. For numbers and statistics see Supplementary Table S1. *p ≤ 0.01; **p ≤ 0.001; ***p ≤ 0.0001.

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