Table 4 Multivariate analysis of different prognostic variables in DSS and RFS of CL-HCC patients using the Cox proportional hazard model.

From: Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma

Variables

DSS

RFS

HR

95%CI

P value

HR

95%CI

P value

Model 1

AFP(ng/ml)

≤20/>20

1.412

0.230–1.737

0.003

1.423

0.237–0.756

0.004

HBsAg

yes/no

0.913

0.326–2.554

0.628

0.958

0.343–2.678

0.925

Model 2

AFP(ng/ml)

≤20/>20

1.514

0.284–1.931

0.028

1.523

0.989–2.947

0.032

HBsAg

yes/no

0.904

0.322–2.542

0.849

0.927

0.330–2.604

0.885

PKM2 expression

low/high

3.032

1.599–5.749

0.001

3.020

1.602–5.695

0.001

Model 3

AFP(ng/ml)

≤20/>20

0.545

0.293–1.013

0.055

0.551

0.298–1.020

0.058

HBsAg

yes/no

0.747

0.257–2.175

0.593

0.753

0.258–2.200

0.604

Tumor size (cm)

≤5/>5

1.461

0.241–1.881

0.019

1.548

0.285–1.053

0.041

Intrahepatic Metastasis

yes/no

0.254

0.060–1.073

0.062

1.236

0.0556–1.521

0.037

TNM stage

(I/II)/(III/VI)

3.011

1.209–7.502

0.018

2.519

1.019–6.230

0.046

Vascular Invasion

yes/no

1.895

0.889–3.993

0.023

2.051

0.988–4.256

0.034

Tumor Differentiation

Poor/well

1.469

0.879–1.942

0.043

1.203

0.735–1.547

0.039

PKM2 expression

low/high

2.283

1.067–4.888

0.034

2.181

1.054–4.513

0.036

  1. Abbreviations: 95% CI = 95% confidence interval; HR = hazard ratio; TNM stage = tumour node metastasis; P-value < 0.05.
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