Table 5 Multivariate analysis of different prognostic variables in DSS and RFS of NCL-HCC patients using the Cox proportional hazard model.
Variables | DSS | RFS | ||||
|---|---|---|---|---|---|---|
HR | 95%CI | P value | HR | 95%CI | P value | |
Model 1 | ||||||
AFP(ng/ml) | ||||||
≤20/>20 | 0.817 | 0.311–2.148 | 0.682 | 0.851 | 0.323–2.236 | 0.743 |
HBsAg | ||||||
yes/no | 0.956 | 0.127–7.221 | 0.966 | 0.961 | 0.127–7.529 | 0.970 |
Model 2 | ||||||
AFP(ng/ml) | ||||||
≤20/>20 | 0.875 | 0.331–2.313 | 0.788 | 0.935 | 0.354–2.471 | 0.892 |
HBsAg | ||||||
yes/no | 0.634 | 0.080–4.994 | 0.665 | 0.638 | 0.081–5.025 | 0.669 |
PKM2 expression | ||||||
low/high | 3.960 | 1.464–10.712 | 0.007 | 3.812 | 1.417–10.254 | 0.008 |
Model 3 | ||||||
AFP(ng/ml) | ||||||
≤20/>20 | 0.627 | 0.217–1.815 | 0.390 | 0.862 | 0.298–2.494 | 0.784 |
HBsAg | ||||||
yes/no | 0.247 | 0.025–2.422 | 0.230 | 0.306 | 0.032–2.932 | 0.304 |
Tumor size (cm) | ||||||
≤5/>5 | 3.734 | 1.160–12.020 | 0.027 | 2.904 | 0.899–4.381 | 0.045 |
Intrahepatic Metastasis | ||||||
yes/no | 5.832 | 1.980–17.095 | 0.011 | 5.354 | 1.810–10.261 | 0.012 |
TNM stage | ||||||
(I/II)/(III/VI) | 1.260 | 0.487–1.776 | 0.016 | 2.276 | 1.093–3.818 | 0.020 |
Vascular Invasion | ||||||
yes/no | 1.108 | 0.217–1.676 | 0.017 | 1.312 | 1.021–3.819 | 0.030 |
Tumor Differentiation | ||||||
Poor/well | 2.387 | 1.302–2.406 | 0.033 | 1.891 | 1.520–3.845 | 0.028 |
PKM2 expression | ||||||
low/high | 4.857 | 1.534–15.375 | 0.007 | 3.996 | 1.314–12.154 | 0.015 |
