Figure 5 | Scientific Reports

Figure 5

From: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Figure 5

Functional cross-talk between liver spheroids and pancreatic islet microtissues. Glucose level during in vitro GTT initiated on day 1 (A), 7 (E) and 13 (I). Dotted lines indicate physiological postprandial glucose range (3.9–7.8 mM). Area under the glucose response curve for day 1 (B), 7 (F) and 13 (J). Insulin level during in vitro GTT initiated on day 1 (C), 7 (G) and 13 (K). Area under the insulin response curve for day 1 (D), 7 (H) and 13 (L). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 using ANOVA with Tukey’s multiple comparison post hoc test. Data shown as mean + SD collected from n = 14 from three independent experiments with three donors of pancreatic islets run at two different laboratories in the first lane and n = 5 from one pancreatic islet donor in the second and third lane.

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