Figure 8

Epitope groups of the anti-HA trimer antibodies determined with competition ELISA. (a) Competition between the pairs of antibodies derived from the protocol Step 1a in Fig. 1 are shown as the heat map in this panel. Three major epitope groups (group I, II and III) are distinguishable as shown in the heat map. The names and associated data of these IgGs are shown next to the competition heat map. The experimental details of the competition ELISA are described in Methods. (b) The description is the same as in panel A for the competition heat map between the pairs of antibodies derived from the protocol Step 1b in Fig. 1.