Figure 4

Differential relative abundance of specific OTUs across the three experimental groups. Metastats model was applied on the 25 most abundant OTUs with frequency >99%. The three experimental groups are indicated as SSc/GI+ (patients with established SSc and gastrointestinal symptoms), SSc/GI- (patients with SSc without gastrointestinal symptoms), and HC (healthy controls). Significant differences are highlighted by different minor letters (P < 0.05).