Figure 1
From: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
Puerarin reduced albuminuria and kidney injury in STZ-induced diabetic eNOS knockout mice. (A) Both diabetic and non-diabetic mice were treated with either vehicle or puerarin when mice developed albuminuria for a total of 9 weeks. Urine samples were collected weekly after starting the treatments for determination of urinary albumin/creatinine ratio. Significant differences were observed starting at 2 weeks after puerarin treatment compared with vehicle-treated diabetic mice. *p < 0.05 and *p < 0.001 compared to vehicle-treated diabetic mice, n = 6. (B) Representative image of periodic acid-Schiff (PAS) stained kidneys. Scale bar: 20 μm. (C,D) Morphometric analysis was performed to determine the glomerular area (C) and % of mesangial area (D) in the glomerular cross sections. **p < 0.01 and ***p < 0.001, n = 6.
