Figure 9 | Scientific Reports

Figure 9

From: Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

Figure 9

Increased co-localization of fibronectin with ER stress marker, KDEL in post-mortem human glaucomatous TM tissues. Post-mortem human TM tissues from age-matched normal (n = 6) and glaucoma (n = 6) were stained with fibronectin (green) and KDEL (red) and co-localization was examined in anterior segment tissues. Representative images are shown at lower (A) scale bar is 100 microns) and higher (B) scale bar is 25 microns) magnification. Both fibronectin and KDEL was increased in human glaucomatous TM tissues. In addition, increased co-localization of fibronectin with KDEL was observed in 5 out of 6 human glaucomatous TM tissues examined.

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