Table 1 Treg intrinsic roles of microRNAs that are differentially expressed between NIKtg and WT Tregs.

From: Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production

miRNA

Fold changea

Targets described in T cells

Predicted effect of decreased miR in Tregs

Citations

miR-21

14.8 down

Dnmt1, SATB1

Loss of Foxp3, acquisition of Teff phenotype

68,84,85

miR-125a

5.5 down

STAT3, IFNγ, IL-13

Decreased suppressive function, acquisition of Teff phenotype

71

miR-146a

3.9 down

STAT1 signaling

Production of IFNγ

67

miR-29b

3.4 down

IFNγ

Production of IFNγ

72–74

miR-10a

2.3 down

Bcl-6

Decrease in Foxp3

69,70

miR-155

2.2 down

SOCS1, SATB1

Decreased CD25-mediated survival, acquisition of Teff phenotype

85,86

  1. afold change in expression levels, NIKtg Tregs vs. WT Tregs.
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