Figure 7 | Scientific Reports

Figure 7

From: Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration

Figure 7

STAT1 is nitrated in melanoma and pancreatic cancer patients. (A) SRM chromatograms of GTGYIK and their isotopic peptide spike-in GTG(13C, 15N)YIK in PBMC obtained from patients. (B) SRM chromatograms of GTGnYIK (nitrated) and their isotopic peptide spike-in GTG(13C, 15N)nYIK in PBMC obtained from patients. (C) Measurement of the ratio of the concentration of GTGnYIK to the concentration of GTGYIK for 9 normal donors (0.14 ± 0.036) and 16 cancer patients (8 melanoma patients and 8 pancreatic cancer patients, 0.30 ± 0.24), p = 0.036, T test).

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