Table 2 Population median parameter estimates for the combination therapy mathematical model.

Maximal amount of replicon levels

POPMAX (Log₁₀ RLU)

21.446

First-order replicon turnover rate for susceptible replicon population

K_turn-s (day⁻¹)

0.650

First-order rate of loss of replicon from cells for susceptible replicon population

K_loss-s (day⁻¹)

0.670

Effective concentration 50 value of LDV for susceptible replicon population

EC_50-D1s (pg/ml)

4.147

Effective concentration 50 value of SOF for susceptible replicon population

EC_50-D2s (pg/ml)

57,356

Drug interaction term for effect for susceptible replicon population

α_s

0.315

−0.15–2.4

First-order replicon turnover rate for replicons resistant to LDV^b

K_turn-R1 (day⁻¹)

0.815

First-order rate of loss of replicon from cells for LDV-resistant replicons

K_loss-R1 (day⁻¹)

0.793

Effective concentration 50 value of LDV for replicons resistant to LDV

EC_50-D1R (pg/ml)

18.625

Drug interaction term for effect for LDV-resistant replicons

α_D1r

0.334

−2.6–0.63

Hill constant for susceptible replicon population to LDV

H_D1-s

0.997

Hill constant for suscpetible replicon population to SOF

H_D2-s

2.985

Hill constant for replicons resistant to LDV

H_D1-R

3.253