Figure 8 | Scientific Reports

Figure 8

From: Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9

Figure 8

A schematic representation of the USP47-mediated EMT in CRCs under hypoxic conditions. Hypoxia-mediated upregulation of Sox9 enhances USP47 expression which, in turn, stabilizes Snail through de-ubiquitination. Snail then translocates to nucleus where it induces the expression of proteins mediating EMT.

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