Table 2 Results of uni- and multi-variate analyses for the association of various factors with chronic kidney disease.

Duration of TDF exposure (per 1 year increase)

1.00

0.96–1.04

0.835

Age (per 1 year increase)^†

1.08

1.07–1.09

<0.001

1.07

1.05–1.08

<0.001

Male sex

1.64

0.93–2.88

0.087

Body weight (per 1 kg increase)^†

1.01

1.00–1.02

0.005

1.02

1.01–1.04

<0.001

Current CD4 count (per 1/µl increase)

1.00

1.00–1.00

0.66

History of AIDS^†

1.56

1.19–2.05

0.001

1.27

0.94–1.71

0.12

Use of nephrotoxic drugs

0.67

0.41–1.10

0.11

Dyslipidemia^†

2.22

1.65–2.99

<0.001

0.97

0.69–1.36

0.85

Diabetes mellitus^†

4.27

2.79–6.55

<0.001

1.96

1.22–3.16

0.006

Hypertension^†

4.73

3.52–6.34

<0.001

1.97

1.40–2.77

<0.001

Smoking^†

0.49

0.37–0.65

<0.001

0.60

0.44–0.82

0.001

Positive hepatitis B antigen

0.98

0.62–1.55

0.92

Positive HCV antibody

1.21

0.79–1.85

0.39

Duration of ART (per 1 year increase)^†

1.07

1.05–1.09

<0.001

1.03

1.00–1.05

0.052

Time from diagnosis of HIV-1 infection (per 1 year increase)

1.04

1.02–1.06

<0.001