Table 3 Operational parameters (estimates ± standard errors) for β-arrestin pathway.

From: A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses

 

Log (KA)

Log (τ)

Log (τ/KA)

Morphine

−6.31 ± 0.10

−0.19 ± 0.02

6.12 ± 0.09

Fentanyl

−6.70 ± 0.19

0.35 ± 0.08

7.05 ± 0.15

TRV130

−6.96 ± 0.99

−1.11 ± 0.15

5.85 ± 0.92

Endomorphine-2

−6.90 ± 0.08

0.29 ± 0.03

7.19 ± 0.06

Buprenorphine

−7.49 ± 0.30

−1.09 ± 0.04

6.40 ± 0.28

  1. Data obtained from concentration-response curves of µ-opioid agonists using the comparative method18 with Damgo as full agonist (Fig. 4). The Hill equation was used for fitting to Damgo data. The values obtained for Damgo for maximal response (95.14) and slope parameter (1.48) were used for all ligands in the Table as Em and n parameters in the operational model and kept fixed as such in the fitting process. Parameter estimates and standard errors of operational parameters log(KA) and log(τ) were produced by global fitting. Log (τ/KA) values and their standard errors were calculated from estimated τ and KA parameters (see Parameter estimation in Methods).
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