Table 1 Characteristics of target antigens.

P.y gene ID	P.f ortholog		Product description	Signature ranking		P.f MS data^c				SP^d	TM^d	SNP densitye	BLASTP identity to human^f	Most immunogenic fragment^g	P.y transcript size	P.y immunogenic fragment size
P.y gene ID	P.f ortholog		Product description	IrrSpz^a	Naturally acquired^b	Spz	Mrz	Tpz	Gmt	SP^d	TM^d	SNP densitye	BLASTP identity to human^f	Most immunogenic fragment^g	P.y transcript size	P.y immunogenic fragment size
PY01533	PF3D7_1304100	MAL13P1.22	DNA ligase I	20	24	2	0	2.2	0	yes	0	0.01	47%, 69%	full-length	2481	2481
PY01606	PF3D7_0918900	PFI0925w	gamma-glutamylcysteine synthetase	1	18	0	4.4	0	0	no	0	0.005	36%, 55%	full-length	3000	3000
PY03673	PF3D7_1405400	PF14_0051	DNA mismatch repair protein, putative	3	N/A	1.3	1.3	0	0	yes	0	0.019	26%, 9%	exons 2+4	4282	1647
PY03832	PF3D7_1233600	PFL1620w	asparagine/aspartate rich protein, putative	5	10	0.2	0	0	0	no	0	0.016	34%, 4%	exon 1 segment 3	9161	2000
PY03168	PF3D7_0304600	PFC0210c	circumsporozoite protein	14	N/A	10.1	0	0	0	yes	1	0.055	33%, 45%	full-length	1176	1176

^a‘Signature antigens’ associated with protection after experimental vaccination with radiation-attenuated sporozoites (RAS)²². ^b‘Signature antigens’ associated with protection against severe malaria in children and young adults in Mali¹⁹. ^cMultidimensional protein identification technology to survey of sporozoite (Spz), merozoite (Mrz), trophozoite (Trp) and gametocyte (Gmt) proteome³⁰. ^dSP, signal peptide; and TM, transmembrane regions of P. falciparum proteins, and P. yoelii orthologues, using SignalP^28,29 and TMHMM2²⁷. ^eSingle nucleotide polymorphism (SPN) density calculated as number of total SNP over the gene length in bp (both derived from PlasmoDB; www.plasmodb.org). ^fBLASTP identity of target proteins to human proteome and query coverage⁸⁷. ^gMost immunogenic P. falciparum open reading frame fragment identified via protein microarray studies²².

Quick links

Search