Figure 7 | Scientific Reports

Figure 7

From: Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis

Figure 7

Schematic overview of the EMT and CSC connection in the tumor progression and the role of CAR in the control of glioblastoma stemness. The tumor microenvironment and extracellular stimuli play crucial roles in CSCs formation and EMT transformation. Both these processes are at the basis of the increase of glioblastoma stemness and favoring the increase of cancer aggressiveness and recurrence. CAR controls the GBM stemness interacting with multiple intracellular pathways decreasing the EMT transition, the CSC formation and the CSC maintenance.

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