Table 1 Antileishmanial activity and cytotoxicity of ABMA and reference drugs.

From: ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

Compound

Axenic amastigotes EC 50 (µM) ± SD

Intramacrophagic amastigotes EC 50 (µM) ± SD

Cytotoxicity on RAW 264.7 macrophages CC 50 (µM) ± SD

Selectivity EC 50 (Axenic amastigotes)/EC 50 (Intra amastigotes)

ABMA

>100

7.1 ± 1.7

25.3 ± 2.4

>14

Miltefosine

1.2 ± 0.5

0.85 ± 0.20

12.5 ± 1.3

1.4

Amphotericin B

0.031 ± 0.002

0.047 ± 0.005

4.5 ± 0.4

<1

  1. The results expressed correspond to the mean of three independent experiments (±SD).
Back to article page