Table 2 EC50 values for the binding of PCSK9 variants to LDLR, as determined by solid-phase immunoassay at pH 7.2 and pH 5.5.

From: Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia

 

EC50 (nM)*

pH 7.2

pH 5.5

Wild-type

112.2 ± 16.8

23.2 ± 3.7

p.(Asp374Tyr)

19.3 ± 9.4

7.4 ± 1.7

p.(Pro331Ala)

97.6 ± 21.7

25.5 ± 7.7

p.(Arg357Cys)

50.9 ± 13.6

13.3 ± 6.7

p.(Ser636Arg)

47.4 ± 7.1

13.9 ± 5.5

p.(His643Arg)

93.7 ± 13.4

44.2 ± 3.2

  1. *Data are reported as mean ± standard deviation.
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