Figure 1 | Scientific Reports

Figure 1

From: Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK

Figure 1

Leptin injection into the VMH increases 2DG uptake in certain peripheral tissues of WT mice but not in those of β-less mice. (a) Rate constant of 2DG uptake in peripheral tissues of WT and β-less mice measured 6 h after injection of saline or leptin into the VMH (n = 6). Gastro-R: red portion of gastrocnemius, Gastro-W: white portion of gastrocnemius, EDL: extensor digitorum longus, BAT: brown adipose tissue, epiWAT: epididymal white adipose tissue. (b,c) Plasma glucose (b) and insulin (c) concentrations in WT and β-less mice at 6 h after injection of leptin into the VMH (n = 6). (d) NE turnover in soleus and Gastro-W muscles of WT mice measured 6 h after saline or leptin injection into the VMH (n = 6 or 7) (unpaired Student’s t test). α-MT: α-methyl-p-tyrosine. All data are means ± S.E.M. *P < 0.05 versus corresponding value for saline injection into WT mice; † P < 0.05 versus corresponding value for leptin injection into WT mice (one-way ANOVA and Bonferroni’s multiple-range test).

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