Figure 4 | Scientific Reports

Figure 4

From: Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

Figure 4

Renal cortical concentrations of adenine based nucleotides relate to glomerular filtration. White squares − Non-diabetic db/m mice (C); Black dots - diabetic db/db mice (D); Blue dots − diabetic db/db mice + 0.6 mg/kg/day MitoQ intragastrically (DMitoQ); Red dots − diabetic db/db mice + 3 mg/kg/day ramipril intragastrically (DRam); Grey bars/dots - diabetic db/db mice + combination of MitoQ and ramipril (DCoAd). n = 6 mice/group. Renal cortical concentrations of (A) adenosine triphosphate (ATP); (B) adenine diphosphate (ADP); (C) ATP:ADP ratio; (D) ATP: adenosine monophosphate ratio (ATP:AMP); (E) AMP; (F) cyclic AMP; (G) Table of Pearson’s correlation coefficients for associations between renal function (FITC sinistrin based GFR) and renal concentrations of adenine molecules. ns – not significant. *P < 0.05 vs C 1 W ANOVA/Tukey’s Post-hoc; † P < 0.05 vs D by 1 W ANOVA/Tukey’s Post-hoc; ‡ P < 0.05 vs C by Student’s unpaired t test; §P < 0.05 vs D by Student’s unpaired t test.

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