Figure 1 | Scientific Reports

Figure 1

From: How gluttonous cell aggregates clear substrates coated with microparticles

Figure 1

Spreading of ECad-GFP cell aggregates on glass substrates coated with fibronectin and decorated with SiO2Carbo1000 MPs. Surface fractions of MPs are (A) ϕ S  = 0.04, (B) ϕ S  = 0.22, (C) ϕ S  = 0.44, (D) ϕ S  = 0.71, (E) ϕ S  = 1.06, and (F) ϕ S  = 1.42. Aggregates are observed in bright field at t = 0, 5, 10, and 15 hours. (G) Time evolution of the monolayer area of spreading aggregates normalized by the initial aggregates radius R 0 without particles and for various ϕ S . (H) Evolution of the spreading velocity of aggregates as a function of ϕ S . Error bars in (G) and (H) are standard deviations with n = 48, 9, 11, 11, 8, and 10 for ϕ S  = 0, 0.04, 0.22, 0.44, 0.71, and 1.06 respectively.

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