Figure 5 | Scientific Reports

Figure 5

From: Overexpression of DYRK1A, a Down Syndrome Candidate gene, Impairs Primordial Germ Cells Maintenance and Migration in zebrafish

Figure 5

Proteomics analysis shows the altered proteins pattern essential for PGCs development in DYRK1A overexpressed embryos. (a) General work flow of Proteomics analysis in this work. (b) Embryos injected with DYRK1A mRNA show increased protein level of DYRK1A. The blots shown are cropped; the uncropped full-length gels are presented in the Supplementary Figure 1. Gene Ontology (GO)-based enrichment analysis of up-regulated (c) and down-regulated (d) proteins (DYRK1A mRNA vs GFP mRNA).

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