Figure 1 | Scientific Reports

Figure 1

From: Therapeutic targeting of extracellular DNA improves the outcome of intestinal ischemic reperfusion injury in neonatal rats

Figure 1

Midgut volvulus generates extracellular DNA and fibrin. (A) Experimental design. Rats were subjected to 360° volvulus for <1 min (Sham; N = 10) or 3 hours (Volvulus: N = 9). Immediately after and 2, 4 and 6 hour after detorsion, cfDNA and TAT levels were measured. (B) CfDNA is released by neutrophils in form of NETs, but can also be emitted from injured cells. In this study, cfDNA levels were significantly increased at two, four and six hours post volvulus as compared to sham operated animals, indicating severe cell injury in the volvulus group. (C) TAT is a marker of hypercoagulability. TAT levels were significantly increased at two, four and six hours post volvulus compared to shams. Data shown as Mean. Statistics: repeated t-test.

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