Figure 6 | Scientific Reports

Figure 6

From: Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach

Figure 6

Results of MTT assay and Western blotting test. (A) The cytotoxic effect of germacrone, curdione, and furanodiene on MCF7 breast cancer cells. Cells were treated with the indicated concentrations of germacrone, curdione, and furanodiene for 24 h and MTT assay was performed. Data represent the mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 for each group versus control. (B,C) Germacrone, curdione, and furanodiene regulated the target protein level. Cells were treated with germacrone, curdione, and furanodiene for various time or concentrations, and the protein expression was determined by western blotting. ERα and ERβ are encoded by the ESR1 and ESR2 gene seperately.

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