Figure 1 | Scientific Reports

Figure 1

From: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton

Figure 1

Coro2b is a novel podocyte specific expressed gene. (a) A phylogenetic tree of the coronin family of WD40-domain containing proteins was generated by comparison of coronin sequences using Clustal Omega. (b) Re-analysis of published omics datasets comparing protein expression of podocytes to glomerular non-podocyte cells identifies Coro2b as a novel podocyte specific expressed protein (previously described podocyte specific proteins are depicted as reference). (c–f) mRNA In-Situ-Hybridization of coronin family members Coro1a, Coro1b, Coro2a and Coro2b confirmed a distinct expression of Coro2b in glomeruli of the developing kidney. Furthermore, Coro2b expression was detected in the developing nervous system as well as developing pituitary gland.

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