Figure 2 | Scientific Reports

Figure 2

From: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton

Figure 2

Coro2b is highly expressed in developing and adult podocytes. (a,b) Immunofluorescence staining for CORO2B and SYNPO could detect a strong expression of CORO2B in podocytes of adult mouse and human glomeruli. (c–e) A Coro2b promotor driven LacZ-reporter allele shows strong Coro2b promotor activity in glomeruli of adult mice. (f–i) Coro2b expression during kidney development was detected earliest at the capillary loop stage, where capillary and mesangial cells start to intrude into the podocyte compartment; formation of primitive foot processes starts to occur at the same developmental stage (ENTACTIN was used to label the glomerular basement membrane). In situ-hybridization for Coro2b mRNA detected respective expression patterns.

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