Figure 4 | Scientific Reports

Figure 4

From: In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty

Figure 4

Implantation of Fully Matured DAPS. (A) Study design: AF/NP DAPS were pre-matured for 10 weeks, implanted into the caudal spines of athymics rats, and analyzed by µCT and histology after 5 weeks. (B) Implantation results: µCT reconstructions and Alcian blue/picrosirius red stained sections of 10-week pre-cultured DAPS after 5 weeks in vivo are displayed along with the 5-week pre-cultured group for side-by-side comparison. There was evidence of bone deposition on the vertebral surface (inset, arrows) but no evidence of fusion. PG-positive staining was not evident in either the AF or NP, and constructs did not integrate into adjacent vertebrae.

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