Table 7 Characteristics of the Finnish and Spanish recipients.

From: Genetic polymorphism related to monocyte-macrophage function is associated with graft-versus-host disease

Characteristic

Finnish recipients*

Spanish recipients

P

Recipient age, median years (range)

49 (18–65)

50 (8–72)

0.085

Donor age, median years (range)

46 (4–65)

47 (3–78)

0.424

Recipient-donor gender, n (%)

 Male-male

73 (28)

87 (33)

0.479§

 Male-female

57 (22)

62 (23)

 

 Female-female

61 (23)

51 (19)

 

 Female-male

71 (27)

66 (25)

 

Diagnosis, n (%)

 Acute myeloid leukemia

73 (28)

88 (33)

0.203§

 Acute lymphoblastic leukemia

39 (15)

24 (9)

0.036§

 Chronic myeloid leukemia

37 (14)

13 (5)

<0.001§

 Myelodysplastic syndrome

20 (8)

26 (10)

0.390§

 Hodgkin’s lymphoma

0 (0)

12 (5)

0.001§

 Non-Hodgkin’s lymphoma

12 (5)

50 (19)

<0.001§

 Myeloma

56 (21)

38 (14)

0.032§

 Aplastic anemia

4 (2)

5 (2)

1.000||

 Other malignancies

21 (8)

11 (4)

0.060§

Stem cell source, n (%)

 Bone marrow

138 (53)

13 (5)

<0.001§

 Peripheral blood

124 (47)

254 (95)

 

Conditioning regimen, n (%)

 Myeloablative

199 (76)

110 (42)

<0.001§

 Reduced intensity conditioning

63 (24)

151 (58)

 

 aGvDH grades III–IV, n (%)

23 (11)

39 (18)

0.044§

 cGvHD, extensive, n (%)

71 (39)

54 (32)

0.156§

  1. aGvHD indicates acute graft-versus-host disease; and cGvHD, chronic graft-versus-host disease.
  2. *Finnish recipients underwent allogeneic HSCT at Helsinki University Hospital, Comprehensive Cancer Center, Stem Cell Transplantation Unit, Finland, between 1993 and 2006.
  3. Spanish recipient underwent allogeneic HSCT at 13 Spanish transplant centers between 2002 and 2014.
  4. The significance of variation between characteristics in the study cohorts was analyzed using the non-parametric Mann–Whitney U-test.
  5. §The significance of variation between characteristics in the study cohorts was analyzed using the Pearson chi-square test.
  6. ||The significance of variation between characteristics in the study cohorts was analyzed using the Fisher’s exact test.