Table 2 Statistical analysis of gene expression patterns: Expression differences between sexes and correlation with age.
Gene | Exp. difference female vs. male (p-value) Linear model | Gender | Correlation with age (p-value) Spearman |
|---|---|---|---|
Bipotential gonad | |||
WT1 | Yes (0.0227)* | Female | No (>0.1) |
Male | Yes (<0.0001) | ||
SF1 | No (>0.1) | Female | No (>0.1) |
Male | No (>0.1) | ||
Sex differentiation | |||
SRY | Yes (<0.0001) | Female | NA |
Male | Yes (<0.0143) | ||
SOX8 | No (>0.1) | Female | No (>0.1) |
Male | No (>0.1) | ||
SOX9 | Yes (<0.0001)* | Female | Yes (0.0155) |
Male | No (0.0689) | ||
SOX10 | No (>0.1) | Female | No (>0.1) |
Male | No (>0.1) | ||
SOX17 | No (>0.1) | Female | No (>0.1) |
Male | No (>0.1) | ||
GLI1 | Yes (<0.0001) | Female | Yes (0.011) |
Male | Yes (0.0002) | ||
PTCH1 | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (0.0072) | ||
AMH | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (0.0014) | ||
AMHR2 | Yes (<0.0167)* | Female | No (>0.1) |
Male | No (>0.1) | ||
ETV5 | Yes (<0.0001) | Female | Yes (<0.0001) |
Male | Yes (0.0295) | ||
WNT2B | Yes (<0.0001) | Female | Yes (<0.0001) |
Male | No (>0.1) | ||
WNT4 | No (>0.1) | Female | No (<0.056) |
Male | No (>0.1) | ||
RSPO1 | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (0.0007) | ||
FOXL2 | Yes (<0.0001) | Female | No (>0.1) |
Male | No (>0.1) | ||
Germ cells | |||
KIT | Yes (<0.0001) | Female | Yes (<0.0001) |
Male | Yes (<0.0001) | ||
KITLG | Yes (<0.0001) | Female | Yes (0.0025) |
Male | Yes (>0.0001) | ||
OCT-4 | Yes (<0.0001)* | Female | Yes (<0.0002) |
Male | Yes (0.0103) | ||
LIN28 | Yes (<0.0001)* | Female | Yes (0.0169) |
Male | No (>0.1) | ||
GAGE10 | No (>0.1) | Female | No (>0.1) |
Male | Yes (0.0003) | ||
GAGE12B | No (>0.1) | Female | No (>0.1) |
Male | Yes (<0.0001) | ||
Steroidogenesis | |||
LHCGR | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (0.0001) | ||
POR | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (<0.0001) | ||
STAR | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (<0.0001) | ||
CYP11A1 | Yes (<0.0001) | Female | No (0.0503) |
Male | Yes (<0.0001) | ||
CYP17A1 | Yes (<0.0001) | Female | Yes (0.0379) |
Male | Yes (<0.0001) | ||
HSD3β1 | Yes (<0.02) | Female | No (>0.1) |
Male | No (>0.1) | ||
HSD3β2 | Yes (<0.0001) | Female | No (0.0869) |
Male | Yes (0.0045) | ||
HSD17β3 | Yes (<0.0001)* | Female | No (0.0700) |
Male | Yes (<0.0001) | ||
HSD17β7 | Yes (<0.0001) | Female | No (>0.1) |
Male | Yes (<0.0001) | ||
ER-α/β | No (>0.1) | Female | No (>0.1) |
Male | No (>0.1) | ||
