Table 3 Analysis of association for each SNP with the cohort of obese individuals according to dominant, recessive and overdominant inheritance models.
Gene and SNP | Inheritance Model | Odds ratio | CI 95% | P value | |
|---|---|---|---|---|---|
IL-10 (rs1800871) | Dominant | GG/GA+AA | 1.384 | (0.793–2.481) | n.s. |
Recessive | AA/GG+GA | 1.894 | (0.672–5.339) | n.s. | |
Overdominant | GA/GG+AA | 1.148 | (0.648–2.032) | n.s. | |
IL-6 (rs1800795) | Dominant | GG/GC+CC | 1.080 | (0.618–1.886) | n.s. |
Recessive | CC/GG+GC | 0.495 | (0.216–1.133) | n.s. | |
Overdominant | GC/GG+CC | 1.523 | (0.865–2.683) | n.s. | |
STAT3 (rs8069645) | Dominant | AA/AG+GG | 1.236 | (0.704–2.170) | n.s. |
Recessive | GG/AA+AG | 0.886 | (0.371–2.114) | n.s. | |
Overdominant | AG/AA+GG | 1.353 | (0.739–2.478) | n.s. | |
SOCS3 (rs8064821) | Dominant | CC/CA+AA | 0.579 | (0.298–1.125) | n.s. |
Recessive | AA/CC+C | 0.310 | (0.061–1.574) | n.s. | |
Overdominant | ACA/CC+AA | 0.699 | (0.345–1.415) | n.s. | |
ERV1/ChemR23 (rs1878022) | Dominant | TT/TC+CC | 1.704 | (0.965–3.010) | <0.05 |
Recessive | CC/TT+TC | 1.355 | (0.705–2.604) | n.s. | |
Overdominant | TC/TT+CC | 1.380 | (0.770–2.474) | n.s. | |
JAK2 (rs7849191) | Dominant | TT/TC+CC | 0.875 | (0.402–1.904) | n.s. |
Recessive | CC/TT+TC | 0.816 | (0.459–1.450) | n.s. | |
Overdominant | TC/TT+CC | 1.130 | (0.648–1.968) | n.s. | |
IL-1β (rs1143634) | Dominant | GG/GA+AA | 0.749 | (0.421–1.331) | n.s. |
Recessive | AA/GG+GA | 0.978 | (0.352–2.718) | n.s. | |
Overdominant | GA/GG+AA | 0.726 | (0.393–1.340) | n.s. | |
