Figure 2

Inhibition of Cx46 hemichannels by calcium at different voltages. Oocytes at a holding potential of −70 mV were subjected to depolarizing pulses of (A) 20 mV, (B) −30 mV and (C) −50 mV. At each voltage different Ca²⁺ concentrations were tested. The colored line indicates the concentration of Ca²⁺ present in the bath. (D) Ca²⁺ inhibition curves for the different voltages used. Data presented as mean ± SEM, the lines indicate the fit to the Hill equation (Table 1).