Table 1 Effects of GABAA receptor β3 mutations L170R, A305V, and T288N on α1β3γ2L receptor channel function.

From: GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

 

α1β3γ2L

α1β3L170Rγ2

α1β3A305Vγ2

α1β3T288Nγ2

Current amplitude, pA

5426 ± 229 pA, n = 15

4408 ± 406 pA, n = 11, p < 0.05

2907 ± 178 pA, n = 10, p < 0.0001

3065 ± 385 pA, n = 9, p < 0.0001

Desensitization extent, %

66 ± 1%, n = 15

73 ± 2%, n = 11, p < 0.01

83 ± 2%, n = 10, p < 0.0001

69 ± 2%, n = 9

Desensitization τ, ms

1236 ± 85 ms, n = 15

808 ± 24 ms, n = 11, p < 0.0001

857 ± 36 ms, n = 10, p < 0.001

1319 ± 80 ms, n = 9

Zinc inhibition, %

13 ± 2%, n = 14

20 ± 1%, n = 11

42 ± 4%, n = 10, p < 0.0001

18 ± 2%, n = 9

Activation τ, ms

0.94 ± 0.03 ms, n = 21

1.25 ± 0.14 ms, n = 11, p < 0.05

1.85 ± 0.13 ms, n = 13, p < 0.0001

0.61 ± 0.03 ms, n = 10, p < 0.05

Deactivation τ, ms

110 ± 3.96 ms, n = 13

145 ± 2.23 ms, n = 11, p < 0.01

176 ± 12.5 ms, n = 13, p < 0.0001

106 ± 3.33 ms, n = 10

  1. Values reported were mean ± S.E.M. One-way ANOVA with Dunnett’s multiple comparisons test was used to determine significance. **** p < 0.0001, *** p < 0.001, ** p < 0.01 and * p < 0.05, respectively, relative to α1β3γ2L.
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