Table 3 Single channel properties of GABAA receptors containing the β3 mutations L170R, A305V, and T288N.

From: GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

 

α1β3γ2L

α1β3L170Rγ2

α1β3A305Vγ2

α1β3T288Nγ2

Number of openings

15128 (n = 7)

42918 (n = 11)

13853 (n = 9)

23189 (n = 6)

10177 (n = 6)

i, pA

2.03 ± 0.37

1.81 ± 0.20

1.52 ± 0.08***

1.59 ± 0.04**

0.93 ± 0.198

Open probability

0.78 ± 0.16

0.28 ± 0.14***

0.42 ± 0.34*

0.52 ± 0.26

0.42 ± 0.22*

Mean open time, ms

12.8 ± 3.17

4.59 ± 0.56****

17.0 ± 3.10**

6.74 ± 1.43***

11.2 ± 4.39

O1, ms (%)

2.21 (72)

3.68 (82)

4.61 (41)

3.71 (83)

1.96 (55)

O2, ms (%)

12.7 (13)

6.82 (15)

21.8 (58)

13.7 (13)

11.4 (37)

O3, ms (%)

59.2 (15)

14.3 (3)

13.7 (13)

44.9 (4)

67.6 (8)

Burst duration, ms

29.4 ± 10.5

10.5 ± 1.47****

42.2 ± 10.0**

25.3 ± 4.90

17.9 ± 5.89*

OB1, ms (%)

3.37 (80)

3.53 (49)

4.35 (46)

10.3 (72)

2.57 (69)

OB2, ms (%)

129 (20)

16.8 (51)

73.1 (54)

60.1 (28)

49.0 (31)

  1. Values represent mean ± S.D. *, **, *** and ****indicate p < 0.05, p < 0.01, p < 0.001 and p < 0.0001 (one-way ANOVA with Dunnett’s multiple comparisons test) statistically different from α1β3γ2, respectively.
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