Table 2 Meta-analysis of the association of childhood leukemia with different types of vaccines from fourteen included studies.
From: Early vaccination protects against childhood leukemia: A systematic review and meta-analysis
Type of vaccines | No. of study | Total sample size (Leukemia/Control) | Heterogeneity | Model | Association with leukemia | Egger’s 2-tailed bias p-value | ||
|---|---|---|---|---|---|---|---|---|
p-value | I 2 | p-value | Odds ratio (95% CI) | |||||
Early vaccination | 7 | 3000/3719581 | 0.0001 | 77.9 | Random | 0.019 | 0.58 (0.36–0.91) | 0.60 |
BCG vaccines | 12 | 3778/3760815 | 0.0001 | 77.7 | Random | 0.117 | 0.73 (0.50–1.08) | 0.47 |
Mumps vaccines | 4 | 3431/4999 | 0.98 | 0 | Fixed | 0.95 | 1.01 (0.82–1.23) | 0.54 |
Hib vaccines | 3 | 2528/4004 | 0.001 | 84.6 | Random | 0.83 | 1.06 (0.64–1.76) | 0.89 |
HBV vaccines | 5 | 2266/3906 | 0.67 | 0 | Fixed | 0.95 | 1.00 (0.85–1.18) | 0.69 |
Triple vaccines | 4 | 1986/2714 | 0.2 | 35.1 | Fixed | 0.56 | 1.10 (0.79–1.53) | 0.99 |
Poliosip vaccines | 4 | 2390/2769 | 0.99 | 0 | Fixed | 0.93 | 0.98 (0.70–1.39) | 0.29 |
MMR vaccines | 4 | 2302/2667 | 0.98 | 0 | Fixed | 0.78 | 0.96 (0.75–1.24) | 0.85 |
Measles vaccines | 6 | 3715/5627 | 0.02 | 59.1 | Random | 0.81 | 1.02 (0.85–1.23) | 0.23 |
Rubella vaccines | 5 | 3548/5267 | 0.96 | 0 | Fixed | 0.98 | 1.00 (0.82–1.23) | 0.10 |
