Figure 6 | Scientific Reports

Figure 6

From: Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid hemorrhage

Figure 6

ST2825 treatment inhibited cell apoptosis in the anterior basal temporal lobe at 24 h post-SAH. (a–j) Representative photomicrographs of TUNEL staining in the inferior basal temporal lobe (a–e, ×100, f–j, ×400). (k) Statistical data revealed that ST2825 treatment significantly reduced the TUNEL-positive cells compared with SAH and DMSO treated groups. (l) MyD88 inhibition reduced the levels of cleaved caspase-3 in the anterior basal temporal lobe at 24 h post SAH. The upper panel shows representative protein levels of cleaved caspase-3. Tubulin was detected as a loading control. The bottom panel shows quantitative data of cleaved caspase-3. Data are expressed as mean ± SD (n = 6 in each group). ***p < 0.001 compared with the sham group, ##p < 0.01 compared with the SAH group, ###p < 0.001 compared with the SAH group, NS, no statistic difference compared with the SAH group.

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