Figure 1 | Scientific Reports

Figure 1

From: T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure

Figure 1

OVA-specific T helper cells are present in high frequency in the spleen of cMy-mOVA-OT-II mice. Splenocytes derived from 8 to 12 weeks old C57BL/6, cMy-mOVA, OT-II, and cMy-mOVA-OT-II mice (n = 8 for each strain) were analyzed by flow cytometry for CD3+CD4+ T helper cells (a), CD3+CD8+ CTL (b), CD3+γδTCR+ γδT cells (c) and the proportion of CD4+TCRVβ5.1/5.2+ T helper cells among all CD3+ T cells (d). Means and SEM are shown. The data were analyzed by ANOVA followed by Bonferroni post hoc tests, if significant differences between the mouse strains were revealed. The P-values of the ANOVA and of significant post hoc tests are given in the figure. The TCR-transgenic and the TCR-non-transgenic strains differed in addition to the CD4+TCRVβ5.1/5.2+ T helper cells also in the proportion of CTL and γδT cells present in the spleen and the respective P-values of Bonferroni post hoc tests are given beside the brackets.

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