Figure 4
From: Insights into gene expression profiles induced by Socs3 depletion in keratinocytes
Transcription regulator network revealed that several regulators of AP-1 are altered in Socs3 cKO. (A) Upstream analysis was performed using IPA software to identify highly regulated transcription factors at 2 and 10 weeks in Socs3 cKO. Activator protein-1 (AP-1)-related transcription factors were differentially regulated at both time points. (B) Predicted mechanistic network of AP-1 regulation; numbers represent log2(fold change) of AP-1–related genes. Different structures of nodes represent different functional classes of gene products. Red indicates DEGs selected for validation. The nature of the relationship between nodes (direct or indirect) is indicated by a solid or dotted line, respectively.
