Figure 4
From: Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system
(A) Hippocampal OXPHOS protein levels 2 h after a single injection of a low dose of ketamine (3 mg kg−1). Complex I NADH dehydrogenase [ubiquinone] flavoprotein 2 (Ndufv2), cytochrome c1, heme protein (Cyc1), and complex I assembly factor (Tmem126B) levels were determined by quantitative proteomics profiling. (B) Correlation analyses of Ndufv2, Cyc1, Ndufaf7, and Tmem126B protein levels with forced swim test (FST) floating time 2 h after a single injection of ketamine (p ≤ 0.05). The results from ketamine-treated animals are normalised to the ones obtained from vehicle treatment (mean value = 1). N = 5 mice per group and time point, ***p ≤ 0.001. P-values were determined by Student’s t-test and significance analysis of microarrays and other omic-datasets (SAM). Error bars represent s.e.m. The correlation coefficient r was calculated by Pearson. The linear regression line is only shown for significant (p ≤ 0.05) correlation coefficients.
