Figure 5
From: Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system
Hippocampal analyses of the antioxidant defense system after a single injection of a low dose of ketamine (3 mg kg−1). (A) Time-dependent Western blot analysis of peroxiredoxin 1 (Prdx1) and peroxiredoxin 3 (Prdx3). N = 5 mice per group and time point. (B) Time-dependent total antioxidant capacity (TAC) analysis. N = 5 mice per group and time point. (C) OxyBlot analysis of the time-dependent protein damage by protein carbonylation in the hippocampus after ketamine treatment. N = 4 mice per group and time point. The results from ketamine-treated animals are normalised to the ones obtained from vehicle treatment (mean value = 1). *p ≤ 0.05, **p ≤ 0.01. P-values were determined by Student’s t-test. Error bars represent s.e.m.
