Figure 5 | Scientific Reports

Figure 5

From: Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression

Figure 5

Association of individual OTUs with treatment and colitis severity. Differential OTU abundance in the caecal microbiota between treatment and baseline conditions were assessed using the R package edgeR. The top 100 OTUs showing the most significant abundance shifts (FDR < 0.01) in at least one tested condition or a strong correlation to at least one parameter of colitis severity (Spearman correlation, rho <|0.5|) are shown. The leftmost columns indicate global OTU size (relative abundance in the entire dataset) in shades of grey and order-level OTU taxonomy in pastel colours (white indicates unknown taxonomy at order level). Blue/red heat maps on the left indicate the fold change (log2|FC|) of OTU abundances between the test conditions; pink/green heat maps on the right indicate correlation strength to colitis severity parameters. OTUs were clustered on the y-axis based on Pearson distances of their fold changes across conditions.

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