Figure 3 | Scientific Reports

Figure 3

From: A New Approach to Deliver Anti-cancer Nanodrugs with Reduced Off-target Toxicities and Improved Efficiency by Temporarily Blunting the Reticuloendothelial System with Intralipid

Figure 3

Intralipid treatment reduces the toxic side effects of Abraxane. (A) Changes of the body weight of rats upon administration of Abraxane, with and without treatment of Intralipid (N = 4). (BI) Light microscopic images of the spleen tissue sections treated with Abraxane, with or without Intralipid. (JM) are from the spleen-tissue sections of the naïve SD rats. Spleen tissue sections were stained with H&E (B,C,F,G and J,K) and TUNEL (D,E,H,I, and L,M). In (D,E,H,I and M), red arrows indicate the apoptotic cells. (BE) are observed from the spleen-tissue sections of the Abraxane administrated, but no Intralipid-treated, animals. (FI) are from the Intralipid-treated animals. (NY) Light microscopic images of the H&E-stained (N,O,R,S, and V,W) and the TUNEL-stained (P,Q,T,U, and X,Y) kidney tissue sections. The red arrows on (Q,U and Y) indicate the apoptotic cells. (Q) Shows an enlarged view of the apoptotic kidney cells.

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