Figure 4

Intralipid treatment reduces the toxic side effects of Marqibo. (A) Changes of the body weight of the rats upon administration of Marqibo, with and without treatment of Intralipid (N = 6). (B–I) Light microscopic images of the spleen tissue sections treated with Marqibo, with or without Intralipid. The spleen tissue sections were stained with H&E (B,C and F,G) and TUNEL (D,E and H,I). In (C), the black arrows point to the mitotic cells and an enlarged view of the spleen mitotic cell is shown. In (D) and (E) The red arrows indicate the apoptotic cells. (E) Shows an enlarged view of the apoptotic cells. (J–Q) Light microscopic images of the (H,E)-stained (J,K and N,O) and the TUNEL-stained (L,M and P,Q) kidney tissue sections. In (K), the black arrows point to the mitotic cells and an enlarged view of kidney mitotic cell is shown. The red arrows on (L,M and Q) indicate the apopto tic cells. (Q) Shows an enlarged view of the apoptotic kidey cells.