Figure 5 | Scientific Reports

Figure 5

From: A New Approach to Deliver Anti-cancer Nanodrugs with Reduced Off-target Toxicities and Improved Efficiency by Temporarily Blunting the Reticuloendothelial System with Intralipid

Figure 5

Intralipid treatment reduces the toxic side effects of Onivyde. (A) Changes of the body weight of rats upon administration of Onivyde, with and without treatment of Intralipid (N = 6). (BI) Light microscopic images of the spleen tissue sections treated with Onivyde, with or without Intralipid. The spleen tissue sections were stained with H&E (B,C and F,G) and TUNEL (D,E and H,I). In (E) and (I), the red arrows indicate the spleen apoptotic cells. (JQ) The light microscopic images of the H&E-stained (J,K and N,O) and the TUNEL-stained (L,M and P,Q) kidney tissue sections. The red arrows on (M and Q) indicate the kidney apoptotic cells.

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