Table 1 Anthropometric and biochemical parameters in control, AHB, AHB after treatment and CHB groups.

From: Diverse Changes of Circulating Fibroblast Growth Factor 21 Levels in Hepatitis B Virus-Related Diseases

Variables

Control (n = 200)

AHB (n = 33)

AHB after treatment (n = 12)

CHB (n = 75)

Age (year)

40.4 ± 9.5

44.7 ± 14.9*

35.9 ± 11.8

35.9 ± 11.7*#

Male (n, %)

67 (34%)

27 (82%)

8 (67%)

55 (73%)

BMI (kg/m2)

22.1 ± 2.2

22.0 ± 2.2

20.2 ± 2.4*,#

22.3 ± 2.8

AST (U/L)†

18.0 (16.0, 21.0)

690.0 (351.5, 845.0)*

54.0 (26.3, 120.5)*,#

157.0 (79.0, 315.0)*,#

ALT (U/L)†

14.0 (10.0, 18.0)

1548.0 (1205.0, 2141.5)*

299.5 (58.3, 422.8)*,#

320.0 (161.0, 754.0)*,#

GGT (U/L)†

16.0 (13.0, 20.0)

175.0 (136.0, 307.5)*

118.0 (83.0, 224.3)*

84.0 (50.0, 166.0)*,#

ALP (U/L)†

64.0 (53.0, 76.0)

144.0 (115.0, 175.0)*

84.0 (79.0, 111.3)*,#

86.0 (66.0, 111.0)*,#

TBil (μmol/L)†

11.2 (8.5, 14.6)

74.4 (36.9, 145.4)*

21.3 (16.2, 26.4)*,#

18.5 (13.3, 41.5)*,#

TBA (μmol/L)†

3.3 (2.3, 4.8)

109.8 (30.8, 212.1)*

7.7 (4.9, 19.6)*,#

16.2 (9.1, 53.9)*,#

CRP (mg/L)†

0.4 (0.2, 0.9)

5.7 (1.9, 15.4)*

/

2.0 (1.6, 4.4)*,#

Cholinesterase (U/L)†

330.0 (290.3, 370.8)

255.0 (226.5, 299.5)*

264.0 (207.8, 316.0)*

268.0 (186.0, 320.0)*

A/G†

1.88 (1.72, 2.05)

1.63 (1.51, 1.78)*

1.81 (1.59, 2.08)

1.60 (1.40, 1.80)*

Albumin (g/L)†

48.0 (46.0, 49.0)

41.0 (38.5, 42.5)*

43.0 (38.5, 45.0)*

42.0 (38.0, 44.0)*

Total protein (g/L)†

73.0 (70.3, 76.0)

64.0 (61.0, 68.5)*

65.0 (62.3, 70.3)*

67.0 (62.0, 71.0)*

TC (mmol/L)†

4.4 (3.9, 5.0)

3.5 (3.2, 4.2)*

/

4.0 (3.7, 4.5)*,#

Triglyceride (mmol/L)†

1.0 (0.7, 1.4)

1.7 (1.1, 2.4)*

/

1.1 (0.8, 1.4)#

HDL-C (μmol/L)†

1.4 (1.2, 1.6)

0.5 (0.3, 0.8)*

/

1.2 (0.6, 1.4)*,#

LDL-C (μmol/L)†

2.7 (2.3, 3.3)

1.9 (1.5, 2.5)*

/

2.2 (1.7, 2.7)*

LgHBV-DNA (IU/ml)†

/

3.7 (1.0, 5.6)

1.0 (1.0, 2.0)#

6.8 (5.4, 7.6)#

FGF21 (pg/ml)†

198.4 (152.8, 272.2)

243.3 (189.6, 451.7)*

112.8 (83.2, 186.3)*,#

142.8 (82.0, 265.3)*,#

  1. *P value < 0.05 vs. control. #P value < 0.05 vs. AHB. †Log-transformed before analysis.
  2. CRP and lipid profiles in the group of AHB after treatment were not measured.
  3. A/G, albumin/globulin; AHB, acute hepatitis B; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, c-reactive protein; CHB, chronic hepatitis B; FGF21, fibroblast growth factor 21; GGT, gamma-glutamyl transpeptidase; HBV, hepatitis B virus; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TBA, total bile acid; TBil, total bilirubin; TC, total Cholesterol.
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