Table 2 Capability of various diversity indices and inequality measures in differentiating between vaginal microbiome samples corresponding to term and preterm delivery outcomes.

From: First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk

Gestation weeks	Number of evaluated microbiome samples			Mathews Correlation Coefficient (MCC)* obtained with various diversity and inequality measures
(Week_N)	PTD	TERM	Total	TCS	Shannon	Simpson	Chao1	Gini	Ricci-Schutz	Atkinson	Theil	Decile ratio (90:10)
8	6	64	70	1 (25.65)	1 (7.59)	1 (8.64)	1 (7.51)	1 (0.90)	0.804	0.578	0.818	0.560
9	7	70	77	1 (21.84)	0.929	0.929	1 (4.51)	0.929	0.833	0.637	0.833	0.637
10	10	77	87	1 (21.84)	0.887	0.887	1 (4.51)	0.947	0.755	0.622	0.839	0.556
11	13	86	99	0.958	0.872	0.823	0.958	0.920	0.763	0.701	0.864	0.593
12	19	97	116	0.937	0.840	0.805	0.937	0.874	0.731	0.673	0.811	0.615
13	28	115	143	0.956	0.842	0.701	0.933	0.843	0.744	0.701	0.817	0.613
14	35	135	170	0.947	0.849	0.676	0.928	0.853	0.774	0.713	0.835	0.633
15	41	157	198	0.940	0.849	0.672	0.923	0.843	0.775	0.687	0.842	0.600
16	51	200	251	0.888	0.758	0.592	0.868	0.849	0.741	0.712	0.836	0.598
17	61	293	354	0.835	0.606	0.481	0.822	0.835	0.729	0.705	0.813	0.550
18	72	364	436	0.829	0.576	0.469	0.820	0.808	0.717	0.699	0.792	0.528
19	82	402	484	0.842	0.572	0.470	0.826	0.808	0.702	0.680	0.793	0.514
20	89	445	534	0.823	0.545	0.437	0.807	0.794	0.688	0.668	0.781	0.491
21	101	466	567	0.751	0.500	0.423	0.732	0.722	0.624	0.603	0.710	0.446
22	109	493	602	0.719	0.452	0.369	0.702	0.704	0.598	0.587	0.686	0.408
23	118	518	636	0.668	0.422	0.338	0.658	0.648	0.544	0.534	0.621	0.372
24	129	554	683	0.629	0.396	0.313	0.620	0.618	0.511	0.498	0.580	0.354
25	140	587	727	0.588	0.353	0.302	0.574	0.590	0.498	0.492	0.552	0.330
26	150	637	787	0.560	0.333	0.301	0.554	0.566	0.474	0.460	0.527	0.308
27	161	684	845	0.522	0.301	0.294	0.523	0.542	0.463	0.450	0.515	0.307
28	170	741	911	0.505	0.310	0.304	0.502	0.524	0.445	0.419	0.490	0.299
29	176	798	974	0.485	0.302	0.299	0.488	0.519	0.445	0.415	0.489	0.293
30	184	850	1034	0.463	0.292	0.290	0.465	0.490	0.418	0.400	0.468	0.289
31	190	908	1098	0.453	0.298	0.299	0.457	0.487	0.413	0.391	0.463	0.281
32	196	962	1158	0.436	0.301	0.302	0.442	0.471	0.388	0.367	0.442	0.273
33	205	1008	1213	0.431	0.310	0.310	0.433	0.448	0.370	0.354	0.423	0.276
34	213	1051	1264	0.427	0.321	0.317	0.428	0.434	0.359	0.347	0.408	0.273
35	219	1099	1318	0.414	0.324	0.320	0.417	0.427	0.355	0.342	0.401	0.272
36	222	1137	1359	0.402	0.317	0.315	0.407	0.418	0.346	0.341	0.390	0.273
37	224	1172	1396	0.391	0.322	0.320	0.395	0.408	0.339	0.331	0.382	0.271
38	224	1333	1557	0.392	0.324	0.321	0.396	0.407	0.343	0.331	0.382	0.266
39	224	1376	1600	0.388	0.322	0.319	0.391	0.403	0.339	0.330	0.377	0.264
40	224	1397	1621	0.383	0.323	0.319	0.388	0.397	0.334	0.328	0.371	0.265

*At each gestation week, the best attained MCC value is indicated in bold face font. A higher MCC value indicates that the metric is able to better differentiate between microbiome samples corresponding to term and preterm delivery outcomes. In cases where a threshold diversity/inequality value could completely differentiate/segregate between samples corresponding to term and preterm delivery outcomes (i.e. MCC = +1), the extent of segregation (ES) is indicated in brackets. A higher ES value indicates relatively better separation between the two groups of samples (term and preterm).

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Table 2 Capability of various diversity indices and inequality measures in differentiating between vaginal microbiome samples corresponding to term and preterm delivery outcomes.

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