Figure 6

In vivo IFN-α responses after challenge infection. IFN-α levels were determined by ELISA in serum of infected animals on days one (a), two (b) and three (a), in BAL fluid on day one (d) and day three (e), and in lung tissue on day three (f) p.i. with R757/10 (H1N2). Asterisks indicate significant differences between two groups as calculated using unpaired one-way ANOVA followed by Tukey’s multiple comparisons test (***P < 0.0001; **P < 0.005; *P < 0.05).