Figure 6

(A) The direction of motion between IDH2/R140Q_AGI-6780 (yellow) and IDH2/WT_AGI-6780 (pink) after 400 ns simulation. (B) Detailed interaction mode of AGI-6780 with IDH2/WT. (C) Evolution of the Cα distances of Ile116-Leu289′ and angles of Ile116-Phe148-Leu289′ in the system of IDH2/WT_AGI-6780 during MD simulation.