Figure 3 | Scientific Reports

Figure 3

From: Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

Figure 3

Histological analysis of pancreatic beta cells. Beta cell mass (A) in each group is shown. Beta cell proliferation (C,D) was analyzed by Ki-67 immunostaining. Scale bar, 50 μm. Expression of cleaved caspase-3 (B) in isolated islets from each group was determined by Western blot. Western blot results were analyzed by densitometry. Data were expressed as mean ± SD or representative images from three to five independent experiments. *p < 0.05, HF and HF + HG versus STD or HG. #p = 0.0012, HG versus STD. Abbreviations: STD, standard diet; HF, high-fat diet; HG, high-glucose water; HF + HG, high-fat diet and high-glucose water; NS, no significant.

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