Figure 5 | Scientific Reports

Figure 5

From: Baculovirus-Mediated miR-214 Knockdown Shifts Osteoporotic ASCs Differentiation and Improves Osteoporotic Bone Defects Repair

Figure 5

Bone healing as evaluated by μCT. OVX-ASCs were mock-transduced (Mock group), co-transduced with BacECre/BacLEBW (LEBW group for BMP2 expression), BacECre/Bac214S (214S group for miR-214 sponge expression) or BacECre/BacLEBW/Bac214S (LEBW/214S group for sustained BMP2/miR-214 sponge expression), loaded into gelatin scaffolds at 1 dpt, and implanted into the critical-size defects (3 mm in diameter) at the left femoral metaphysis of osteoporotic rats. (a) μCT images at weeks 2 (2W) and 5 (5 W). n = 8 for each group at 5 W; n = 4 for each group at 2 W. The defect areas are indicated by dashed box. The color intensity indicates bone density. (b) BMD of cortical bone from defect center to mid-shaft of the LEBW/214S group.

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